Update on major clones of methicillin-resistant Staphylococcus aureus colonizing and/or infecting humans and its distribution in Brazil

Autores

  • Thaina Miranda da Costa Programa de Pós-Graduação em Patologia - Faculdade de Medicina - Universidade Federal Fluminense - Niterói - Brasil.
  • Valéria Vieira Polo Universitário de Nova Friburgo - Universidade Federal Fluminense - Nova Friburgo - Brasil.
  • Fábio Aguiar Alves Programa de Mestrado em Ensino em Ciências e Meio Ambiente - Centro Universitário de Volta Redonda - UniFOA

DOI:

https://doi.org/10.47385/cadunifoa.v7.n19.1106

Palavras-chave:

Methicillin-resistant Staphylococcus aureus Nasal colonization Infection Genotypes

Resumo

Staphylococcus aureus is a bacterium well known for its ability to acquire genes for resistance to antimicrobial drugs. A few years after the discovery of penicillin, which initiated the era of antibiotics, resistance to this drug had already been reported in hospitals and in a few decades also became a problem within the communities. Likewise, shortly after the introduction of methicillin as a therapeutic option, the resistance was observed. The indiscriminate use of antibiotics is an important factor contributing to the emergence of new resistant strains. This pathogen has the ability to spread rapidly and asymptomatically among healthy individuals. Infections caused by Methicillin-Resistant Staphylococcus aureus (MRSA) have reached a global share and are increasing in hospitals and community, including countries that previously had a low prevalence of MRSA history, exposing a significant diversity of clones identified. Outbreaks of infections caused by strains of Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) have been reported worldwide, including Brazil, where there is currently an epidemic of CA-MRSA. The present article intends to review the molecular epidemiology of methicillin-resistant Staphylococcus aureus and its evolution, with a focus on the clones distributed in Brazil.

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Referências

AIRES DE SOUSA M.; CRISOSTOMO M.I.; SANCHES I.S.; WU J.S.; FUZHONG J.; TOMASZ A. ; DE LENCASTRE H. Frequent recovery of a single clonal type of multidrug-resistant Staphylococcus aureus from patients in two hospitals in Taiwan and China. J Clin Microbiol. v. 41, n. 1, p. 159-163, Jan. 2003.

AIRES DE SOUSA M.; DE LENCASTRE H.; SANTOS SANCHES I.; KIKUCHI K.; TOTSUKA K. ; TOMASZ A. Similarity of antibiotic resistance patterns and molecular typing properties of methicillin-resistant Staphylococcus aureus isolates widely spread in hospitals in New York City and in a hospital in Tokyo, Japan. Microb Drug Resist. v. 6, n. 3, p. 253-258, Fall. 2000.

AIRES DE SOUSA M.; MIRAGAIA M.; SANCHES I.S.; AVILA S.; ADAMSON I.; CASAGRANDE S.T.; BRANDILEONE M.C.; PALACIO R.; DELL’ACQUA L.; HORTAL M.; CAMOU T.; ROSSI A.; VELAZQUEZ-MEZA M.E.; ECHANIZ-AVILES G.; SOLORZANO-SANTOS F.; HEITMANN I. ; DE LENCASTRE H. Three-year assessment of methicillin-resistant Staphylococcus aureus clones in Latin America from 1996 to 1998. J Clin Microbiol. Lisboa, v. 39, n. 6, p. 2197-2205, Jun. 2001.

ALLEGRANZI B.; BAGHERI NEJAD S.; COMBESCURE C.; GRAAFMANS W.; ATTAR H.; DONALDSON L. ; PITTET D. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet. Geneva, v. 377, n. 9761, p. 228-241, Jan 15. 2011.

BERGLUND C.; MOLLING P.; SJOBERG L. ; SODERQUIST B. Predominance of staphylococcal cassette chromosome mec (SCCmec) type IV among methicillin-resistant Staphylococcus aureus (MRSA) in a Swedish county and presence of unknown SCCmec types with Panton-Valentine leukocidin genes. Clin Microbiol Infect. Orebro, v. 11, n. 6, p. 447-456, Jun. 2005.

BRASIL Lei 9431 de 6 de março de 1997. Dispõem sobre a obrigatoriedade da manutenção de programa de controle de infecções hospitalares pelos hospitais do país. Diário Oficial da República Federativa do Brasil, Brasília, DF. [cited 2009, 03 set.]. Available from: http://www6.senado.gov.br/sicon/ExecutaPesquisaLegislacao

CECCARELLI G.; D’ETTORRE G. ; VULLO V. Purulent Meningitis as an Unusual Presentation of Staphylococcus aureus Endocarditis: A Case Report and Literature Review. Case Report Med. v. 2011, n. p. 7352-7365, 2011.

CHAMBERS H.F. ; DELEO F.R. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. San Francisco, v. 7, n. 9, p. 629-641, Sep. 2009.

CHARLEBOIS E.D.; BANGSBERG D.R.; MOSS N.J.; MOORE M.R.; MOSS A.R.; CHAMBERS H.F. ; PERDREAU-REMINGTON F. Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco. Clin Infect Dis. San Francisco, v. 34, n. 4, p. 425-433, Feb 15. 2002.

CONLY J.M. ; JOHNSTON B.L. The emergence of methicillin-resistant Staphylococcus aureus as a community-acquired pathogen in Canada. Can J Infect Dis. v. 14, n. 5, p. 249-251, Sep. 2003.

COREY G.R. Staphylococcus aureus bloodstream infections: definitions and treatment. Clin Infect Dis. v. 48 Suppl 4, n. p. S254-259, May 15. 2009.

DAILEY L.; COOMBS G.W.; O’BRIEN F.G.; PEARMAN J.W.; CHRISTIANSEN K.; GRUBB W.B. ; RILEY T.V. Methicillin-resistant Staphylococcus aureus, Western Australia. Emerg Infect Dis. v. 11, n. 10, p. 1584-1590, Oct. 2005.

DANCER S.J. The effect of antibiotics on methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. v. 61, n. 2, p. 246-253, Feb. 2008.

DE MIRANDA O.P.; SILVA-CARVALHO M.C.; RIBEIRO A.; PORTELA F.; CORDEIRO R.P.; CAETANO N.; VIDAL C.F. ; FIGUEIREDO A.M. Emergence in Brazil of methicillin-resistant Staphylococcus aureus isolates carrying SCCmecIV that are related genetically to the USA800 clone. Clin Microbiol Infect. v. 13, n. 12, p. 1165-1172, Dec. 2007.

DEURENBERG R.H. ; STOBBERINGH E.E. The evolution of Staphylococcus aureus. Infect Genet Evol. Maastricht, v. 8, n. 6, p. 747-763, Dec. 2008.

The molecular evolution of hospital- and community-associated methicillin-resistant Staphylococcus aureus. Curr Mol Med. v. 9, n. 2, p. 100-115, Mar. 2009.

DOS SANTOS SOARES M.J.; DA SILVA-CARVALHO M.C.; FERREIRA-CARVALHO B.T. ; FIGUEIREDO A.M. Spread of methicillin-resistant Staphylococcus aureus belonging to the Brazilian epidemic clone in a general hospital and emergence of heterogenous resistance to glycopeptide antibiotics among these isolates. J Hosp Infect. v. 44, n. 4, p. 301-308, Apr. 2000.

ERIKSEN K.R. [“Celbenin”-resistant staphylococci]. Ugeskr Laeger. v. 123, n. p. 384-386, Mar 17. 1961.

FORTES C.Q.; ESPANHA C.A.; BUSTORFF F.P.; ZAPPA B.C.; FERREIRA A.L.; MOREIRA R.B.; PEREIRA N.G.; FOWLER V.G., JR. ; DESHMUKH H. First reported case of infective endocarditis caused by community-acquired methicillin-resistant Staphylococcus aureus not associated with healthcare contact in Brazil. Braz J Infect Dis. v. 12, n. 6, p. 541-543, Dec. 2008.

FOWLER V.G., JR.; MIRO J.M.; HOEN B.; CABELL C.H.; ABRUTYN E.; RUBINSTEIN E.; COREY G.R.; SPELMAN D.; BRADLEY S.F.; BARSIC B.; PAPPAS P.A.; ANSTROM K.J.; WRAY D.; FORTES C.Q.; ANGUERA I.; ATHAN E.; JONES P.; VAN DER MEER J.T.; ELLIOTT T.S.; LEVINE D.P. ; BAYER A.S. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA. v. 293, n. 24, p. 3012-3021, Jun 22. 2005.

GENESTIER A.L.; MICHALLET M.C.; PREVOST G.; BELLOT G.; CHALABREYSSE L.; PEYROL S.; THIVOLET F.; ETIENNE J.; LINA G.; VALLETTE F.M.; VANDENESCH F. ; GENESTIER L. Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils. J Clin Invest. Lyon, v. 115, n. 11, p. 3117-3127, Nov. 2005.

GORWITZ R.J. Understanding the success of methicillin-resistant Staphylococcus aureus strains causing epidemic disease in the community. J Infect Dis. v. 197, n. 2, p. 179-182, Jan 15. 2008.

HANSSEN A.M. ; ERICSON SOLLID J.U. SCCmec in staphylococci: genes on the move. FEMS Immunol Med Microbiol. v. 46, n. 1, p. 8-20, Feb. 2006.

ITO T.; MA X.X.; TAKEUCHI F.; OKUMA K.; YUZAWA H. ; HIRAMATSU K. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob Agents Chemother. v. 48, n. 7, p. 2637-2651, Jul. 2004.

International Working Group on the Staphylococcal Cassette Chromosome elements. Currently identified SCCmec types in S. aureus strains. Japan: IWG-SCC elements; 2009-2010 [cited 2011, 26 Dec]. Available from: http://www.sccmec.org/Pages/SCC_TypesEN.html.

JEVONS M.P.; COE A.W. ; PARKER M.T. Methicillin resistance in staphylococci. Lancet. v. 1, n. 7287, p. 904-907, Apr 27. 1963.

KATAYAMA Y.; ITO T. ; HIRAMATSU K. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. Tokyo, v. 44, n. 6, p. 1549-1555, Jun. 2000.

KENNEDY A.D.; OTTO M.; BRAUGHTON K.R.; WHITNEY A.R.; CHEN L.; MATHEMA B.; MEDIAVILLA J.R.; BYRNE K.A.; PARKINS L.D.; TENOVER F.C.; KREISWIRTH B.N.; MUSSER J.M. ; DELEO F.R. Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification. Proc Natl Acad Sci U S A. v. 105, n. 4, p. 1327-1332, Jan 29. 2008.

KLEVENS R.M.; MORRISON M.A.; NADLE J.; PETIT S.; GERSHMAN K.; RAY S.; HARRISON L.H.; LYNFIELD R.; DUMYATI G.; TOWNES J.M.; CRAIG A.S.; ZELL E.R.; FOSHEIM G.E.; MCDOUGAL L.K.; CAREY R.B. ; FRIDKIN S.K. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA. v. 298, n. 15, p. 1763-1771, Oct 17. 2007.

KONDO Y.; ITO T.; MA X.X.; WATANABE S.; KREISWIRTH B.N.; ETIENNE J. ; HIRAMATSU K. Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob Agents Chemother. v. 51, n. 1, p. 264-274, Jan. 2007.

LEE B.Y.; MCGLONE S.M.; WONG K.F.; YILMAZ S.L.; AVERY T.R.; SONG Y.; CHRISTIE R.; EUBANK S.; BROWN S.T.; EPSTEIN J.M.; PARKER J.I.; BURKE D.S.; PLATT R. ; HUANG S.S. Modeling the Spread of Methicillin-Resistant Staphylococcus aureus (MRSA) Outbreaks throughout the Hospitals in Orange County, California. Infect Control Hosp Epidemiol. v. 32, n. 6, p. 562-572, Jun. 2011.

LINDSAY J.A. ; HOLDEN M.T. Staphylococcus aureus: superbug, super genome? Trends Microbiol. London, v. 12, n. 8, p. 378-385, Aug. 2004.

LO W.T. ; WANG C.C. Panton-Valentine leukocidin in the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection. Pediatr Neonatol. v. 52, n. 2, p. 59-65, Apr. 2011.

MELO M.C.; SILVA-CARVALHO M.C.; FERREIRA R.L.; COELHO L.R.; SOUZA R.R.; GOBBI C.N.; ROZENBAUM R.; SOLARI C.A.; FERREIRA-CARVALHO B.T. ; FIGUEIREDO A.M. Detection and molecular characterization of a gentamicin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) clone in Rio de Janeiro that resembles the New York/Japanese clone. J Hosp Infect. v. 58, n. 4, p. 276-285, Dec. 2004.

MELTER O.; SANTOS SANCHES I.; SCHINDLER J.; AIRES DE SOUSA M.; MATO R.; KOVAROVA V.; ZEMLICKOVA H. ; DE LENCASTRE H. Methicillin-resistant Staphylococcus aureus clonal types in the Czech Republic. J Clin Microbiol. v. 37, n. 9, p. 2798-2803, Sep. 1999.

NAIMI T.S.; LEDELL K.H.; COMO-SABETTI K.; BORCHARDT S.M.; BOXRUD D.J.; ETIENNE J.; JOHNSON S.K.; VANDENESCH F.; FRIDKIN S.; O’BOYLE C.; DANILA R.N. ; LYNFIELD R. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA. v. 290, n. 22, p. 2976-2984, Dec 10. 2003.

OLIVEIRA G.A.; FARIA J.B.; LEVY C.E. ; MAMIZUKA E.M. Characterization of the Brazilian endemic clone of methicillin-resistant Staphylococcus aureus (MRSA) from hospitals throughout Brazil. Braz J Infect Dis. v. 5, n. 4, p. 163-170, Aug. 2001.

PEREZ L.R. ; D’AZEVEDO P.A. Clonal types and antimicrobial resistance profiles of methicillin-resistant Staphylococcus aureus isolates from hospitals in south Brazil. Rev Inst Med Trop Sao Paulo. v. 50, n. 3, p. 135-137, May-Jun. 2008.

RAMMELKAMP C.H. ; MAXON T. Resistance of Staphylococcus aureus to the Action of Penicillin. Proc Soc Exp Biol Med. v. 51, n. p. 386-389, December 1942.

RAMOS R.L.; TEIXEIRA L.A.; ORMONDE L.R.; SIQUEIRA P.L.; SANTOS M.S.; MARANGONI D. ; FIGUEIREDO A.M. Emergence of mupirocin resistance in multiresistant Staphylococcus aureus clinical isolates belonging to Brazilian epidemic clone III::B:A. J Med Microbiol. v. 48, n. 3, p. 303-307, Mar. 1999.

REINERT C.; MCCULLOCH J.A.; WATANABE S.; ITO T.; HIRAMATSU K. ; MAMIZUKA E.M. Type IV SCCmec found in decade old Brazilian MRSA isolates. Braz J Infect Dis. v. 12, n. 3, p. 213-216, Jun. 2008.

RIBEIRO A.; CORONADO A.Z.; SILVA-CARVALHO M.C.; FERREIRA-CARVALHO B.T.; DIAS C.; ROZENBAUM R.; DEL PELOSO P.F.; DA COSTA FERREIRA LEITE C.; TEIXEIRA L.A. ; FIGUEIREDO A.M. Detection and characterization of international community-acquired infections by methicillin-resistant Staphylococcus aureus clones in Rio de Janeiro and Porto Alegre cities causing both community- and hospital-associated diseases. Diagn Microbiol Infect Dis. v. 59, n. 3, p. 339-345, Nov. 2007.

RIBEIRO A.; DIAS C.; SILVA-CARVALHO M.C.; BERQUO L.; FERREIRA F.A.; SANTOS R.N.; FERREIRA-CARVALHO B.T. ; FIGUEIREDO A.M. First report of infection with community-acquired methicillin-resistant Staphylococcus aureus in South America. J Clin Microbiol. v. 43, n. 4, p. 1985-1988, Apr. 2005.

RIZEK C.F.; MATTE M.H.; DROPA M.; MAMIZUKA E.M.; DE ALMEIDA L.M.; LINCOPAN N.; MATTE G.R. ; GERMANO P.M. Identification of Staphylococcus aureus carrying the mecA gene in ready-to-eat food products sold in Brazil. Foodborne Pathog Dis. v. 8, n. 4, p. 561-563, Apr. 2011.

ROBINSON D.A. ; ENRIGHT M.C. Multilocus sequence typing and the evolution of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect. Bath, v. 10, n. 2, p. 92-97, Feb. 2004.

RODRIGUEZ-NORIEGA E. ; SEAS C. The changing pattern of methicillin-resistant staphylococcus aureus clones in Latin America: implications for clinical practice in the region. Braz J Infect Dis. v. 14 Suppl 2, n. p. S87-96, Dec. 2010.

RODRIGUEZ-NORIEGA E.; SEAS C.; GUZMAN-BLANCO M.; MEJIA C.; ALVAREZ C.; BAVESTRELLO L.; ZURITA J.; LABARCA J.; LUNA C.M.; SALLES M.J. ; GOTUZZO E. Evolution of methicillin-resistant Staphylococcus aureus clones in Latin America. Int J Infect Dis. v. 14, n. 7, p. e560-566, Jul. 2010.

ROSSI F. The challenges of antimicrobial resistance in Brazil. Clin Infect Dis. v. 52, n. 9, p. 1138-1143, May. 2011.

ROZENBAUM R.; SAMPAIO M.G.; BATISTA G.S.; GARIBALDI A.M.; TERRA G.M.; SOUZA M.J.; VIEIRA E.N.; SILVA-CARVALHO M.C.; TEIXEIRA L.A. ; FIGUEIREDO A.M. The first report in Brazil of severe infection caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Braz J Med Biol Res. v. 42, n. 8, p. 756-760, Aug. 2009.

ROZENBAUM R.; SILVA-CARVALHO M.C.; SOUZA R.R.; MELO M.C.; GOBBI C.N.; COELHO L.R.; FERREIRA R.L.; FERREIRA-CARVALHO B.T.; SCHUENCK A.L.; NEVES F.M.; SILVA L.R. ; FIGUEIREDO A.M. Molecular characterization of methicillin-resistant Staphylococcus aureus disseminated in a home care system. Infect Control Hosp Epidemiol. v. 27, n. 10, p. 1041-1050, Oct. 2006.

SA-LEAO R.; SANTOS SANCHES I.; DIAS D.; PERES I.; BARROS R.M. ; DE LENCASTRE H. Detection of an archaic clone of Staphylococcus aureus with low-level resistance to methicillin in a pediatric hospital in Portugal and in international samples: relics of a formerly widely disseminated strain? J Clin Microbiol. v. 37, n. 6, p. 1913-1920, Jun. 1999.

SADER H.S.; PIGNATARI A.C.; HOLLIS R.J. ; JONES R.N. Evaluation of interhospital spread of methicillin-resistant Staphylococcus aureus in Sao Paulo, Brazil, using pulsed-field gel electrophoresis of chromosomal DNA. Infect Control Hosp Epidemiol. v. 15, n. 5, p. 320-323, May. 1994.

SAID-SALIM B.; MATHEMA B.; BRAUGHTON K.; DAVIS S.; SINSIMER D.; EISNER W.; LIKHOSHVAY Y.; DELEO F.R. ; KREISWIRTH B.N. Differential distribution and expression of Panton-Valentine leucocidin among community-acquired methicillin-resistant Staphylococcus aureus strains. J Clin Microbiol. Newark, v. 43, n. 7, p. 3373-3379, Jul. 2005.

SCHUENCK R.P.; NOUER S.A.; WINTER CDE O.; CAVALCANTE F.S.; SCOTTI T.D.; FERREIRA A.L.; GIAMBIAGI-DE MARVAL M. ; DOS SANTOS K.R. Polyclonal presence of non-multiresistant methicillin-resistant Staphylococcus aureus isolates carrying SCCmec IV in health care-associated infections in a hospital in Rio de Janeiro, Brazil. Diagn Microbiol Infect Dis. v. 64, n. 4, p. 434-441, Aug. 2009.

SCRIBEL L.V.; SILVA-CARVALHO M.C.; SOUZA R.R.; SUPERTI S.V.; KVITKO C.H.; FIGUEIREDO A.M. ; ZAVASCKI A.P. Clinical and molecular epidemiology of methicillin-resistant Staphylococcus aureus carrying SCCmecIV in a university hospital in Porto Alegre, Brazil. Diagn Microbiol Infect Dis. v. 65, n. 4, p. 457-461, Dec. 2009.

SHORE A.C.; DEASY E.C.; SLICKERS P.; BRENNAN G.; O’CONNELL B.; MONECKE S.; EHRICHT R.; COLEMAN D.C. Detection of Staphylococcal Cassette Chromosome mec Type XI Carrying Highly Divergent mecA, mecI, mecR1, blaZ, and ccr Genes in Human Clinical Isolates of Clonal Complex 130 Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. v. 55, n. 8, p. 3765-3773, Aug. 2011.

SILVA-CARVALHO M.C.; BONELLI R.R.; SOUZA R.R.; MOREIRA S.; DOS SANTOS L.C.; DE SOUZA CONCEICAO M.; DE MELLO JUNIOR S.J.; CARBALLIDO J.M.; RITO P.N.; VIEIRA V.V.; TEIXEIRA L.A. ; SA FIGUEIREDO A.M. Emergence of multiresistant variants of the community-acquired methicillin-resistant Staphylococcus aureus lineage ST1-SCCmecIV in 2 hospitals in Rio de Janeiro, Brazil. Diagn Microbiol Infect Dis. v. 65, n. 3, p. 300-305, Nov. 2009.

SOUSA-JUNIOR F.C.; SILVA-CARVALHO M.C.; FERNANDES M.J.; VIEIRA M.F.; PELLEGRINO F.L.; FIGUEIREDO A.M.; DE MELO M.C. ; MILAN E.P. Genotyping of methicillin-resistant Staphylococcus aureus isolates obtained in the Northeast region of Brazil. Braz J Med Biol Res. v. 42, n. 10, p. 877-881, Oct. 2009.

STEVENS M.P.; BEARMAN G.; ROSATO A. ; EDMOND M. Community-acquired methicillin resistant Staphylococcus aureus in a women’s collegiate basketball team. South Med J. v. 101, n. 10, p. 1067-1068, Oct. 2008.

TEIXEIRA L.A.; RESENDE C.A.; ORMONDE L.R.; ROSENBAUM R.; FIGUEIREDO A.M.; DE LENCASTRE H. ; TOMASZ A. Geographic spread of epidemic multiresistant Staphylococcus aureus clone in Brazil. J Clin Microbiol. v. 33, n. 9, p. 2400-2404, Sep. 1995.

UDO E.E.; PEARMAN J.W. ; GRUBB W.B. Genetic analysis of community isolates of methicillin-resistant Staphylococcus aureus in Western Australia. J Hosp Infect. v. 25, n. 2, p. 97-108, Oct. 1993.

VANDENESCH F.; NAIMI T.; ENRIGHT M.C.; LINA G.; NIMMO G.R.; HEFFERNAN H.; LIASSINE N.; BES M.; GREENLAND T.; REVERDY M.E. ; ETIENNE J. Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis. v. 9, n. 8, p. 978-984, Aug. 2003.

VIVONI A.M.; DIEP B.A.; DE GOUVEIA MAGALHAES A.C.; SANTOS K.R.; RILEY L.W.; SENSABAUGH G.F. ; MOREIRA B.M. Clonal composition of Staphylococcus aureus isolates at a Brazilian university hospital: identification of international circulating lineages. J Clin Microbiol. v. 44, n. 5, p. 1686-1691, May. 2006.

WALRAVEN C.J.; LINGENFELTER E.; ROLLO J.; MADSEN T. ; ALEXANDER D.P. Diagnostic and Therapeutic Evaluation of Community-acquired Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infections in the Emergency Department. J Emerg Med. n. p., Apr 25. 2011.

ZHANG K.; MCCLURE J.A.; ELSAYED S. ; CONLY J.M. Novel staphylococcal cassette chromosome mec type, tentatively designated type VIII, harboring class A mec and type 4 ccr gene complexes in a Canadian epidemic strain of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. v. 53, n. 2, p. 531-540, Feb. 2009.

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28-03-2017

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DA COSTA, T. M.; VIEIRA, V.; ALVES, F. A. Update on major clones of methicillin-resistant Staphylococcus aureus colonizing and/or infecting humans and its distribution in Brazil. Cadernos UniFOA, Volta Redonda, v. 7, n. 19, p. 93–105, 2017. DOI: 10.47385/cadunifoa.v7.n19.1106. Disponível em: https://revistas.unifoa.edu.br/cadernos/article/view/1106. Acesso em: 4 out. 2022.

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Ciências Biológicas e da Saúde

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